• Erosive esophagitis (short-term IV)
• GERD when oral not possible
• Zollinger‑Ellison syndrome
• Duodenal/gastric ulcer (IV alternative)
• Stress ulcer prophylaxis*

• Usual adult: 40 mg IV once daily
• Zollinger‑Ellison: 60 mg q12h, individualize
• IV injection: over ≥2.5 min (4 mg/mL)
• Infusion: dilute in 100 mL D5W/NS, 20‑30 min

1. Add 10 mL sterile water for injection
2. Swirl gently – 4 mg/mL clear solution
3. For IV push: withdraw dose & inject slowly
4. For infusion: transfer to 100 mL D5W/NS

Do not refrigerate after reconstitution – precipitation risk.

• Hypersensitivity to omeprazole / benzimidazoles
• Rilpivirine (significant interaction)
• Atazanavir / nelfinavir (reduces antiviral effect)

• Exclude gastric malignancy before use
• Acute interstitial nephritis – discontinue
• Hypomagnesemia with prolonged use
• Avoid with clopidogrel (reduced effect)

commonheadache, nausea, diarrhea, injection site pain

serious rare anaphylaxis, SJS, pancreatitis, hypomagnesemia

• ↓ absorption ketoconazole, erlotinib, etc.
• ↑ methotrexate, cilostazol, warfarin (monitor)
• Avoid clopidogrel, atazanavir, rilpivirine

Supplied: 1 vial (40 mg) with package insert